Fine module 70 - -


Module's content:

Genes:

SYMBOLTITLEMINMAXNCBI human gene summary
2010002M12RIKRIKEN cDNA 2010002M12 gene3.438.04NCBI mm gene  
2410066E13RIKRIKEN cDNA 2410066E13 gene5.639.09NCBI mm gene  
4930523C07RIKRIKEN cDNA 4930523C07 gene6.1711.09NCBI mm gene  
ADD1adducin 1 (alpha)8.7111.03NCBI mm gene  Summary: Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq].
BC043934cDNA sequence BC0439344.618.77NCBI mm gene  
C330024D12RIKpyroglutamyl-peptidase I-like4.827.53NCBI mm gene  
C630004H02RIKRIKEN cDNA C630004H02 gene6.099.95NCBI mm gene  
CD2CD2 antigen5.3812.71NCBI mm gene  
DGKAdiacylglycerol kinase, alpha5.7812.71NCBI mm gene  
DUSP10dual specificity phosphatase 105.7010.46NCBI mm gene  
DYRK2dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 25.589.19NCBI mm gene  
FAM169Bfamily with sequence similarity 169, member B4.6210.61NCBI mm gene  
FAM53Bfamily with sequence similarity 53, member B6.1611.05NCBI mm gene  
FOXO1forkhead box O15.9610.95NCBI mm gene  Summary: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq].
GM10673predicted gene 106734.109.75NCBI mm gene  
HIVEP2human immunodeficiency virus type I enhancer binding protein 24.4210.49NCBI mm gene  
IGF2Rinsulin-like growth factor 2 receptor5.8710.89NCBI mm gene  Summary: The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. In mice, the homologous gene is expressed only from the maternal chromosome. [provided by RefSeq].
INADLInaD-like (Drosophila)5.538.63NCBI mm gene  
ITPR2inositol 1,4,5-triphosphate receptor 26.4710.90NCBI mm gene  
LTBlymphotoxin B6.1311.44NCBI mm gene  
OAS1C2'-5' oligoadenylate synthetase 1C5.047.42NCBI mm gene  
PLEKHG2pleckstrin homology domain containing, family G (with RhoGef domain) member 25.909.50NCBI mm gene  
POU6F1POU domain, class 6, transcription factor 15.988.99NCBI mm gene  
RAPGEF4Rap guanine nucleotide exchange factor (GEF) 45.3310.28NCBI mm gene  
RASGRP1RAS guanyl releasing protein 14.7812.42NCBI mm gene  Summary: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq].
RCBTB1regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 15.099.93NCBI mm gene  
S1PR1sphingosine-1-phosphate receptor 15.0912.20NCBI mm gene  Summary: The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq].
SCML4sex comb on midleg-like 4 (Drosophila)6.3310.29NCBI mm gene  
SLC37A3solute carrier family 37 (glycerol-3-phosphate transporter), member 35.409.71NCBI mm gene  
SPNA2spectrin alpha 26.3510.60NCBI mm gene  
TECPR1tectonin beta-propeller repeat containing 17.0110.26NCBI mm gene  
TNFRSF26tumor necrosis factor receptor superfamily, member 265.639.68NCBI mm gene  
TRIB2tribbles homolog 2 (Drosophila)5.8210.62NCBI mm gene  Summary: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
UBE2Hubiquitin-conjugating enzyme E2H7.5711.03NCBI mm gene  
USP3ubiquitin specific peptidase 37.7210.98NCBI mm gene  
ZHX2zinc fingers and homeoboxes 26.218.99NCBI mm gene  
ZYG11Bzyg-ll homolog B (C. elegans)7.049.95NCBI mm gene