| SYMBOL | TITLE | MIN | MAX | NCBI human gene summary |
|---|---|---|---|---|
| 1700047G07RIK | RIKEN cDNA 1700047G07 gene | 5.58 | 7.88 | NCBI mm gene |
| 4930444G20RIK | RIKEN cDNA 4930444G20 gene | 5.17 | 7.89 | NCBI mm gene |
| AF362573 | 6.02 | 10.79 | NCBI mm gene | |
| AY036118 | cDNA sequence AY036118 | 9.98 | 13.49 | NCBI mm gene |
| CD209A | CD209a antigen | 9.38 | 11.91 | NCBI mm gene Summary: This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants. |
| GM10785 | predicted gene 10785 | 5.81 | 8.82 | NCBI mm gene |
| GM14214 | ribosomal protein L7A pseudogene | 4.37 | 6.29 | NCBI mm gene |
| GNAS | GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus | 8.11 | 11.17 | NCBI mm gene Summary: This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq]. |
| ND6 | 6.94 | 11.90 | NCBI mm gene | |
| OLFR598 | olfactory receptor 598 | 4.27 | 6.37 | NCBI mm gene |
| RNU7 | U7 small nuclear RNA | 3.32 | 5.67 | NCBI mm gene |
| RPRL1 | ribonuclease P RNA-like 1 | 7.41 | 9.74 | NCBI mm gene |
| TRIO | triple functional domain (PTPRF interacting) | 6.57 | 10.49 | NCBI mm gene |