| Symbol | Assignment | Title | min
expression | max
expression | mean
weight | min
weight | max
weight | NCBI
human
gene
summary |
|---|
| EYA2 | C56 F288 | eyes absent 2 homolog (Drosophila) | 5.38 | 9.13 | 0.034374 | 0 | 0.13255 | Summary: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined. [provided by RefSeq]. |
| TBX21 | C19 F99 | T-box 21 | 5.13 | 12.06 | 0.031895 | 0.031895 | 0.031895 | Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq]. |
| KLF12 | C19 F98 | Kruppel-like factor 12 | 4.32 | 9.16 | 0.021456 | 0 | 0.37135 | |
| ZBTB38 | C F | zinc finger and BTB domain containing 38 | 6.16 | 9.26 | 0.01971 | 0 | 0.050395 | Summary: The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types. [provided by RefSeq]. |
| EOMES | C19 F97 | eomesodermin homolog (Xenopus laevis) | 4.65 | 11.44 | 0.017053 | 0 | 0.29515 | |
| KCNIP3 | C19 F98 | Kv channel interacting protein 3, calsenilin | 4.98 | 8.83 | 0.015745 | 0 | 0.27251 | |
| SMAD3 | C53 F278 | MAD homolog 3 (Drosophila) | 6.37 | 11.09 | 0.013856 | 0.013856 | 0.013856 | Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq]. |
| EYA1 | C16 F71 | eyes absent 1 homolog (Drosophila) | 4.74 | 10.07 | 0.011109 | 0 | 0.19227 | Summary: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Four transcript variants encoding three distinct isoforms have been identified for this gene. [provided by RefSeq]. |
| RUNX3 | C18 F92 | runt related transcription factor 3 | 5.54 | 11.10 | 0.0082472 | 0 | 0.10309 | |
| ZFPM1 | C5 F42 | zinc finger protein, multitype 1 | 6.43 | 11.40 | 0.0056027 | 0.0056027 | 0.0056027 | |
| POU4F2 | C F | POU domain, class 4, transcription factor 2 | 6.15 | 7.91 | 0.0019267 | 0.0019267 | 0.0019267 | |
| ZFP105 | C62 F303 | zinc finger protein 105 | 3.77 | 6.99 | 0.0019182 | 0 | 0.033199 | |
| KDM6A | C51 F267 | 4lysine (K)-specific demethylase 6A | 5.48 | 10.13 | 0.0018937 | 0 | 0.042609 | Summary: This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. [provided by RefSeq]. |
| ZBTB16 | C56 F288 | zinc finger and BTB domain containing 16 | 5.28 | 11.53 | 0.00084057 | 0 | 0.094564 | Summary: This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq]. |
Model's
repressors:
| Symbol | Assignment | Title | min
expression | max
expression | mean
weight | min
weight | max
weight | NCBI
human
gene
summary |
|---|
| PAX5 | C33 F176 | paired box gene 5 | 5.22 | 12.45 | -0.0079905 | -0.089893 | 0 | |
| NR4A2 | C32 F171 | nuclear receptor subfamily 4, group A, member 2 | 5.12 | 11.76 | -0.004713 | -0.10604 | 0 | Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]. |