Fine module 300 - Lymphocytes marker - CCR6, CCR7, LTA,

Model's activators:

Symbol	Assignment	Title	min expression	max expression	mean weight	min weight	max weight	NCBI human gene summary
FOXO1	C16 F70	forkhead box O1	5.53	11.18	0.13854	0.13854	0.13854	Summary: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq].
RCBTB1	C16 F70	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	4.86	10.16	0.10712	0.10712	0.10712
NCOA3	C61 F302	nuclear receptor coactivator 3	6.73	11.09	0.099884	0.099884	0.099884	Summary: The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq].
CBX7	C1 F3	chromobox homolog 7	6.88	10.34	0.087816	0.087816	0.087816
IRF4	C25 F136	interferon regulatory factor 4	4.19	11.17	0.024156	0.024156	0.024156
ZFP318	C25 F145	zinc finger protein 318	5.47	11.21	0.019678	0	0.27672
EGR2	C32 F172	early growth response 2	5.58	10.57	0.018788	0	0.063094	Summary: The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq].
ID3	C50 F262	inhibitor of DNA binding 3	5.07	11.03	0.01866	0	0.046651
ARNTL	C59 F297	aryl hydrocarbon receptor nuclear translocator-like	5.25	10.15	0.013391	0	0.048596
ZBTB16	C56 F288	zinc finger and BTB domain containing 16	5.28	11.53	0.0092141	0	0.11518	Summary: This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq].
ZGPAT	C F	zinc finger, CCCH-type with G patch domain	7.19	9.50	0.0091365	0	0.13705
RFX5	C33 F180	regulatory factor X, 5 (influences HLA class II expression)	5.97	9.40	0.0082449	0	0.18551	Summary: A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq].
EZH1	C F	enhancer of zeste homolog 1 (Drosophila)	7.55	10.40	0.0071001	0	0.12289
CIITA	C25 F136	class II transactivator	5.39	11.43	0.0066515	0	0.093536	Summary: This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq].
ZFP281	C1 F1	zinc finger protein 281	6.00	10.33	0.0012	0	0.26999

Model's repressors:

Symbol	Assignment	Title	min expression	max expression	mean weight	min weight	NCBI human gene summary
ERG	C40 F204	avian erythroblastosis virus E-26 (v-ets) oncogene related	5.20	10.69	-0.01156	-0.20007
KLF12	C19 F98	Kruppel-like factor 12	4.32	9.16	-0.010843	-0.18767
RORA	C19 F99	RAR-related orphan receptor alpha	4.90	10.28	-0.0031409	-0.032123
TBX21	C19 F99	T-box 21	5.13	12.06	-0.0022191	-0.038407	Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq].
MBD2	C F	methyl-CpG binding domain protein 2	7.86	12.36	-0.0016809	-0.021011
IRF6	C58 F296	interferon regulatory factor 6	5.65	10.18	-2.6626e-005	-0.0029955	Summary: This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. This protein is involved in palate formation. [provided by RefSeq].