| Symbol | Assignment | Title | min
expression | max
expression | mean
weight | min
weight | max
weight | NCBI
human
gene
summary |
|---|
| RREB1 | C F | ras responsive element binding protein 1 | 7.10 | 9.85 | 0.059238 | 0.059238 | 0.059238 | Summary: The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]. |
| THRA | C50 F264 | thyroid hormone receptor alpha | 5.65 | 8.74 | 0.038031 | 0 | 0.062459 | Summary: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]. |
| ENO1 | C16 F76 | enolase 1, alpha non-neuron | 8.97 | 12.57 | 0.035792 | 0.035792 | 0.035792 | |
| PBX2 | C F | pre B-cell leukemia transcription factor 2 | 6.89 | 9.86 | 0.02878 | 0 | 0.029704 | |
| KDM5B | C13 F61 | lysine (K)-specific demethylase 5B | 6.20 | 11.09 | 0.024262 | 0 | 0.028581 | |
| TRPS1 | C45 F232 | trichorhinophalangeal syndrome I (human) | 5.37 | 10.92 | 0.01587 | 0 | 0.1759 | Summary: This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq]. |
| HDAC4 | C53 F278 | histone deacetylase 4 | 7.08 | 9.77 | 0.014166 | 0 | 0.020302 | Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq]. |
| MXD4 | C62 F303 | Max dimerization protein 4 | 7.23 | 10.19 | 0.0083323 | 0 | 0.028842 | |
| CEBPE | C F | CCAAT/enhancer binding protein (C/EBP), epsilon | 5.76 | 9.49 | 0.0077346 | 0 | 0.24861 | Summary: The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq]. |
| FOXO3 | C75 F320 | forkhead box O3 | 6.63 | 10.58 | 0.0066641 | 0.0066641 | 0.0066641 | |
| CEBPB | C24 F122 | CCAAT/enhancer binding protein (C/EBP), beta | 6.36 | 11.45 | 0.0062033 | 0 | 0.010339 | |
| DACH1 | C43 F214 | dachshund 1 (Drosophila) | 4.52 | 9.44 | 0.0034748 | 0 | 0.11169 | Summary: This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
| FLI1 | C25 F143 | Friend leukemia integration 1 | 6.39 | 11.01 | 0.003191 | 0 | 0.0057438 | |
| ATF7 | C F | activating transcription factor 7 | 8.10 | 10.16 | 0.0030682 | 0 | 0.053103 | |
| ZFP238 | C33 F180 | zinc finger protein 238 | 6.27 | 10.17 | 0.001062 | 0 | 0.018382 | |
| NCOA4 | C81 F332 | nuclear receptor coactivator 4 | 8.04 | 12.01 | 0.00094933 | 0 | 0.0061028 | Summary: This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq]. |
Model's
repressors:
| Symbol | Assignment | Title | min
expression | max
expression | mean
weight | min
weight | max
weight | NCBI
human
gene
summary |
|---|
| MYCL1 | C26 F150 | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | 5.37 | 9.25 | -0.058849 | -0.098081 | 0 | |
| TBX21 | C19 F99 | T-box 21 | 5.44 | 11.95 | -0.029644 | -0.26022 | 0 | Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq]. |
| KDM2B | C34 F186 | lysine (K)-specific demethylase 2B | 6.44 | 10.53 | -0.02418 | -0.16001 | 0 | |
| ZEB1 | C48 F251 | zinc finger E-box binding homeobox 1 | 5.54 | 10.20 | -0.01959 | -0.12594 | 0 | Summary: This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described. |
| RFX5 | C33 F180 | regulatory factor X, 5 (influences HLA class II expression) | 6.30 | 9.27 | -0.0022648 | -0.014988 | 0 | Summary: A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq]. |
| INSM1 | C27 F157 | insulinoma-associated 1 | 6.30 | 10.79 | -0.0019166 | -0.086247 | 0 | |
| ETV3 | C48 F249 | ets variant gene 3 | 7.24 | 12.53 | -0.000931 | -0.041895 | 0 | |