Coarse module 34 - antigen processing and presentation



MsigDB enrichement:
  • C1 - Mouse genomic bands
  • C2 - curated gene sets
  • C3 - motif gene sets
  • C5 - GO gene sets
    CategorySet titleBrief descriptionEnrichment p-value#set genes in module
    C117qB1Genes in cytogenetic band 17qB14.8628e-01316
    c2ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UPHepatic graft versus host disease (GVHD), day 7: up-regulated in allogeneic vs syngeneic bone marrow transplant.7.1255e-01014
    c2PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DNAntigen processing and presentation genes down-regulated in JY cells (B lymphocytes) treated with trichostatin A (TSA) [PubChem=5562].5.6531e-0098
    c2MARKEY_RB1_ACUTE_LOF_UPGenes up-regulated in adult fibroblasts with inactivated RB1 [Gene ID=5925] by Cre-lox: acute loss of function (LOF) of RB1.4.5091e-00816
    c2KEGG_ANTIGEN_PROCESSING_AND_PRESENTATIONAntigen processing and presentation4.7746e-0077
    c2KIM_LRRC3B_TARGETSImmune response genes up-regulated in zenograft tumors formed by SNU-601 cells (gastric cancer) made to express LRRC3B [Gene ID=116135].1.3538e-0055
    c2WIELAND_UP_BY_HBV_INFECTIONGenes induced in the liver during hepatitis B (HBV) viral clearance in chimpanzees.2.6852e-0058
    c2CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_DNGenes down-regulated by 2-methoxyestradiol (2ME2) [PubChem=1573] in the MM.1S cell line (multiple myeloma) sensitive to dexamethasone [PubChem=5743].5.6986e-0057
    c2CASTELLANO_NRAS_TARGETS_UPGenes up-regulated in MEF cells (embryonic fibroblast) isolated from NRAS [Gene ID=4893] knockout mice.0.00011556
    c2ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UPHepatic graft versus host disease (GVHD), day 35: genes up-regulated in allogeneic vs syngeneic bone marrow transplant.0.00013089
    c2LINDSTEDT_DENDRITIC_CELL_MATURATION_BMaturation of monocyte-derived dendritic cells (DC) in response to inflammatory stimuli: genes up-regulated both at 8 hr and 48 hr after the stimulation (cluster B).0.00021395
    c2SENGUPTA_EBNA1_ANTICORRELATEDGenes whose reduced expression in nasopharyngeal carinoma (NPC) correlated most with the increased expression of EBNA1 [Gene ID=3783774], a latent gene of Epstein-Barr virus (EBV).0.000330816
    c2DER_IFN_ALPHA_RESPONSE_UPGenes up-regulated in HT1080 cells (fibrosarcoma) by treatment with interferon alpha for 6 h.0.000345955
    c2DER_IFN_BETA_RESPONSE_UPGenes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon beta for 6 h.0.000360146
    c2DER_IFN_GAMMA_RESPONSE_UPGenes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon gamma for 6 h.0.000431455
    c2REACTOME_P53_INDEPENDENT_DNA_DAMAGE_RESPONSEGenes involved in p53-Independent DNA Damage Response0.000440724
    c2KEGG_PROTEASOMEProteasome0.000514994
    c2REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APCGenes involved in Autodegradation of Cdh1 by Cdh1:APC/C0.000597754
    c2REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3GGenes involved in Vif-mediated degradation of APOBEC3G0.000597754
    c2REACTOME_STABILIZATION_OF_P53Genes involved in Stabilization of p530.000597754
    c2REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASEGenes involved in Regulation of ornithine decarboxylase (ODC)0.000689524
    c2REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1Genes involved in SCF-beta-TrCP mediated degradation of Emi10.000689524
    c2REACTOME_SIGNALING_BY_WNTGenes involved in Signaling by Wnt0.000689524
    c3STTTCRNTTT_V$IRF_Q6Genes with promoter regions [-2kb,2kb] around transcription start site containing motif STTTCRNTTT. Motif does not match any known transcription factor0.000135758