| Category | Set
title | Brief
description | Enrichment
p-value | #set
genes
in
module |
|---|
| c2 | HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN | Genes down-regulated in hematopoietic precursor cells conditionally expressing HOXA9 and MEIS1 [Gene ID=3205, 4211]. | 1.8097e-014 | 27 |
| c2 | MCLACHLAN_DENTAL_CARIES_UP | Genes up-regulated in pulpal tissue extracted from carious teeth. | 6.5294e-011 | 33 |
| c2 | MCLACHLAN_DENTAL_CARIES_DN | Genes down-regulated in pulpal tissue extracted from carious teeth. | 1.9609e-010 | 34 |
| c2 | MARKEY_RB1_ACUTE_LOF_UP | Genes up-regulated in adult fibroblasts with inactivated RB1 [Gene ID=5925] by Cre-lox: acute loss of function (LOF) of RB1. | 3.9742e-010 | 36 |
| c2 | BASSO_CD40_SIGNALING_UP | Gene changed by CD40 [Gene ID=958] signaling in Ramos cells (EBV negative Burkitt lymphoma). | 1.186e-009 | 22 |
| c2 | RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN | Genes down-regulated in peripheral blood monocytes by CSF2RB (GM-CSF) [Gene ID=1437] and IL4 [Gene ID=3565]. | 1.2887e-009 | 38 |
| c2 | LIAN_LIPA_TARGETS_6M | Genes up-regulated at 6 months of age in lungs from LIPA [Gene ID=3988] knockout mice, which display pulmonary pathology. | 1.5481e-009 | 20 |
| c2 | RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP | Genes up-regulated in peripheral blood mononucleocytes by HGF [Gene ID=3082] compared to those regulated by CSF2RB (GM-CSF) [Gene ID=1437] and IL4 [Gene ID=3565]. | 2.5168e-009 | 44 |
| c2 | LIAN_LIPA_TARGETS_3M | Genes up-regulated at 3 months of age in lungs from LIPA [Gene ID=3988] knockout mice, which display pulmonary pathology. | 2.9243e-009 | 18 |
| c2 | VERHAAK_AML_WITH_NPM1_MUTATED_UP | Genes up-regulated in acute myeloid leukemia (AML) patients with mutated NPM1 [Gene ID=4869]. | 3.8737e-009 | 27 |
| c2 | ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP | Hepatic graft versus host disease (GVHD), day 35: genes up-regulated in allogeneic vs syngeneic bone marrow transplant. | 3.994e-008 | 25 |
| c2 | MULLIGHAN_MLL_SIGNATURE_2_UP | The 'MLL signature 2': genes up-regulated in pediatric AML (acute myeloid leukemia) with rearranged MLL [Gene ID=4297] compared to the AML cases with intact MLL and NPM1 [Gene ID=4869]. | 7.2302e-008 | 35 |
| c2 | MORI_IMMATURE_B_LYMPHOCYTE_UP | Up-regulated genes in the B lymphocyte developmental signature based on expression profiling of lymphomas from the Emu-myc transgenic mice: the immature B stage. | 2.076e-007 | 13 |
| c2 | MULLIGHAN_MLL_SIGNATURE_1_UP | The 'MLL signature 1': genes up-regulated in pediatric AML (acute myeloid leukemia) with rearranged MLL [Gene ID=4297] compared to all AML cases with the intact gene. | 3.1138e-007 | 32 |
| c2 | REACTOME_SIGNALING_IN_IMMUNE_SYSTEM | Genes involved in Signaling in Immune system | 4.7125e-007 | 31 |
| c2 | YU_MYC_TARGETS_DN | Genes down-regulated in B cell lymphoma tumors expressing an activated form of MYC [Gene ID=4609]. | 8.0285e-007 | 14 |
| c2 | POOLA_INVASIVE_BREAST_CANCER_UP | Genes up-regulated in atypical ductal hyperplastic tissues from patients with (ADHC) breast cancer vs those without the cancer (ADH). | 8.7884e-007 | 31 |
| c2 | KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS | Fc gamma R-mediated phagocytosis | 1.2974e-006 | 14 |
| c2 | WIELAND_UP_BY_HBV_INFECTION | Genes induced in the liver during hepatitis B (HBV) viral clearance in chimpanzees. | 1.9819e-006 | 17 |
| c2 | APPEL_IMATINIB_RESPONSE | Genes up-regulated by imatinib [PubChem ID=5291] during dendritic cell differentiation. | 2.5351e-006 | 10 |
| c2 | RODWELL_AGING_KIDNEY_UP | Genes whose expression increases with age in normal kidney. | 3.0945e-006 | 31 |
| c2 | RUTELLA_RESPONSE_TO_HGF_UP | Genes up-regulated in peripheral blood monocytes by HGF [Gene ID=3082]. | 5.2922e-006 | 38 |
| c2 | KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY | NOD-like receptor signaling pathway | 6.6386e-006 | 11 |
| c2 | SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP | Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). | 9.0082e-006 | 34 |
| c2 | KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY | Toll-like receptor signaling pathway | 9.3306e-006 | 13 |
| c2 | ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP | Hepatic graft versus host disease (GVHD), day 7: up-regulated in allogeneic vs syngeneic bone marrow transplant. | 9.5011e-006 | 19 |
| c2 | VALK_AML_CLUSTER_5 | Top 40 genes from cluster 5 of acute myeloid leukemia (AML) expression profile; 96% of the samples are FAB M4 or M5 subtype. | 1.2662e-005 | 8 |
| c2 | JAATINEN_HEMATOPOIETIC_STEM_CELL_DN | Genes up-regulated in CD133+ [Gene ID=8842] cells (hematopoietic stem cells, HSC) compared to the CD133- cells. | 1.5783e-005 | 24 |
| c2 | FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN | Genes down-regulated in monocyte-derived dendritic cells (MDDC) after stimulation with galecin-1 (lectin, LGALS1) [Gene ID=3956] compared to that with bacterial lipopolysaccharide (LPS). | 1.6117e-005 | 37 |
| c2 | REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY | Genes involved in Costimulation by the CD28 family | 2.6798e-005 | 10 |
| c2 | KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION | Intestinal immune network for IgA production | 2.8842e-005 | 9 |
| c2 | GAL_LEUKEMIC_STEM_CELL_DN | Genes down-regulated in leukemic stem cells (LSC), defined as CD34+CD38- [Gene ID=947, 952] cells from AML (acute myeloid leukemia patients) compared to the CD34+CD38+ cells. | 2.91e-005 | 23 |
| c2 | RAMALHO_STEMNESS_DN | Genes depleted in embryonic, neural and hematopoietic stem cells. | 2.948e-005 | 13 |
| c2 | ROSS_AML_WITH_MLL_FUSIONS | Top 100 probe sets for pediatric acute myeloid leukemia (AML) subtypes with chimeric MLL fusions [Gene ID=4297]. | 3.3179e-005 | 12 |
| c2 | WILENSKY_RESPONSE_TO_DARAPLADIB | Atherosclerotic process genes whose coronary expression changed after darapladib [PubChem=9939609] treatment. | 3.6995e-005 | 8 |
| c2 | TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN | Genes down-regulated in normal hematopoietic progenitors by RUNX1-RUNX1T1 [Gene ID=861, 862] fusion. | 3.9725e-005 | 22 |
| c2 | MORI_MATURE_B_LYMPHOCYTE_UP | Up-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the mature B | 4.0968e-005 | 14 |
| c2 | REACTOME_TOLL_LIKE_RECEPTOR_4_CASCADE | Genes involved in Toll Like Receptor 4 (TLR4) Cascade | 4.0978e-005 | 7 |
| c2 | NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP | Top 100 probe sets contrubuting to the positive side of the 1st principal component; predominantly associated with spindle cell and pleomorphic sarcoma samples. | 4.1812e-005 | 13 |
| c2 | ZHAN_MULTIPLE_MYELOMA_CD2_UP | Top 50 up-regulated genes in cluster CD-2 of multiple myeloma samples with the characteristic expression spike of CCND3 [Gene ID=896]. | 5.0002e-005 | 9 |
| c2 | KEGG_ASTHMA | Asthma | 5.4979e-005 | 6 |
| c2 | KEGG_AUTOIMMUNE_THYROID_DISEASE | Autoimmune thyroid disease | 6.0081e-005 | 7 |
| c2 | KLEIN_PRIMARY_EFFUSION_LYMPHOMA_DN | Genes down-regulated in AIDS-related primary effusion lymphoma (PEL) samples compared to other tumor subtypes and normal B lymphocytes. | 6.5091e-005 | 11 |
| c2 | KEGG_LEISHMANIA_INFECTION | Leishmania infection | 7.8955e-005 | 11 |
| c2 | THUM_SYSTOLIC_HEART_FAILURE_UP | Genes up-regulated in samples with systolic heart failure compared to normal hearts. | 8.2671e-005 | 31 |
| c2 | KEGG_LYSOSOME | Lysosome | 8.9015e-005 | 15 |
| c2 | HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_DN | Genes down-regulated in hematopoietic progenitor cells (HPC) of T lymphocyte and NK (natural killer) lineage. | 9.527e-005 | 11 |
| c2 | TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN | Genes down-regulated in CD34+ [Gene ID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [Gene ID=4928, 3205] off a retroviral vector at 8 days after transduction. | 0.00010041 | 19 |
| c2 | HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_UP | Genes up-regulated during differentiation from small pre-BII to immature B lymphocyte. | 0.00010532 | 9 |
| c2 | RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP | Genes up-regulated in ALL (acute lymphoblastic leukemia) blasts after 1 week of treatment with glucocorticoids. | 0.00011438 | 11 |
| c2 | KEGG_GRAFT_VERSUS_HOST_DISEASE | Graft-versus-host disease | 0.00012007 | 7 |
| c2 | RUTELLA_RESPONSE_TO_HGF_DN | Genes down-regulated in peripheral blood monocytes by HGF [Gene ID=3082]. | 0.00016012 | 22 |
| c2 | KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY | B cell receptor signaling pathway | 0.00016253 | 11 |
| c2 | KEGG_ALLOGRAFT_REJECTION | Allograft rejection | 0.0001645 | 7 |
| c2 | GOLDRATH_ANTIGEN_RESPONSE | Genes up-regulated at the peak of an antigen response of naive CD8+ [Gene ID=925, 926] T-cells. | 0.00019133 | 35 |
| c2 | FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP | Genes differentially expressed in kidney biopsies from patients with acute transplant rejection compared to the biopsies from patients with well functioning kidneys more than 1-year post transplant. | 0.00019496 | 13 |
| c2 | DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_DN | Genes down-regulated in CD34+ [Gene ID=947] cells isolated from bone marrow of CML (chronic myelogenous leukemia) patients, compared to those from normal donors. | 0.00019594 | 14 |
| c2 | FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP | Genes up-regulated in monocyte-derived dendritic cells (MDDC) after stimulation with galecin-1 (lectin, LGALS1) [Gene ID=3956] compared to that with bacterial lipopolysaccharide (LPS). | 0.00021138 | 38 |
| c2 | MORI_LARGE_PRE_BII_LYMPHOCYTE_DN | Down-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the Large Pre-BII stage. | 0.00022595 | 10 |
| c2 | KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS | Systemic lupus erythematosus | 0.00024868 | 12 |
| c2 | REACTOME_CLATHRIN_DERIVED_VESICLE_BUDDING | Genes involved in Clathrin derived vesicle budding | 0.00025594 | 8 |
| c2 | REACTOME_COLLAGEN_MEDIATED_ACTIVATION_CASCADE | Genes involved in Collagen-mediated activation cascade | 0.00028139 | 6 |
| c2 | CROONQUIST_NRAS_SIGNALING_UP | Genes up-regulated in ANBL-6 cell line (multiple myeloma, MM) expressing a constantly active form of NRAS [Gene ID=4893] off a plasmid vector compared to those grown in the presence of IL6 [Gene ID=3569]. | 0.00029306 | 7 |
| c2 | KEGG_TYPE_I_DIABETES_MELLITUS | Type I diabetes mellitus | 0.00029306 | 7 |
| c2 | IVANOVA_HEMATOPOIESIS_MATURE_CELL | Genes in the expression cluster 'MBC Shared': up-regulated in mature blood cell populations from adult bone marrow and fetal liver. | 0.00032178 | 14 |
| c2 | KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION | Antigen processing and presentation | 0.00040095 | 8 |
| c2 | MORI_PRE_BI_LYMPHOCYTE_DN | Down-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the Pre-BI stage. | 0.00042147 | 11 |
| c2 | REACTOME_MEMBRANE_TRAFFICKING | Genes involved in Membrane Trafficking | 0.00049516 | 8 |
| c2 | SMID_BREAST_CANCER_NORMAL_LIKE_UP | Genes up-regulated in the normal-like subtype of breast cancer. | 0.00059117 | 34 |
| c2 | STEARMAN_TUMOR_FIELD_EFFECT_UP | Up-regulated genes in the 'Field Effect' signature of normal lung tissue adjacent to the tumor. | 0.00060655 | 8 |
| c2 | CHIANG_LIVER_CANCER_SUBCLASS_INTERFERON_UP | All marker genes up-regulated in the 'interferon' subclass of hepatocellular carcinoma (HCC). | 0.00065032 | 5 |
| c2 | KLEIN_TARGETS_OF_BCR_ABL1_FUSION | Genes changed in pre-B lymphoblastic leukemia cells with BCR-ABL1 fusion [Gene ID=613, 25] vs normal pre-B lymphocytes. | 0.00071431 | 6 |
| c5 | DEFENSE_RESPONSE | Genes annotated by the GO term GO:0006952. Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. | 1.2338e-007 | 27 |
| c5 | IMMUNE_SYSTEM_PROCESS | Genes annotated by the GO term GO:0002376. Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. | 1.9764e-005 | 28 |
| c5 | RESPONSE_TO_EXTERNAL_STIMULUS | Genes annotated by the GO term GO:0009605. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. | 2.349e-005 | 24 |
| c5 | INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS | Genes annotated by the GO term GO:0042095. The chemical reactions and pathways resulting in the formation of interferon-gamma. | 2.3981e-005 | 5 |
| c5 | INFLAMMATORY_RESPONSE | Genes annotated by the GO term GO:0006954. The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. | 2.8489e-005 | 15 |
| c5 | INTERFERON_GAMMA_PRODUCTION | Genes annotated by the GO term GO:0032609. The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. | 9.8393e-005 | 5 |
| c5 | HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS | Genes annotated by the GO term GO:0004553. Catalysis of the hydrolysis of any O-glycosyl bond. | 0.00013339 | 6 |
| c5 | INTRACELLULAR_SIGNALING_CASCADE | Genes annotated by the GO term GO:0007242. A series of reactions within the cell that occur as a result of a single trigger reaction or compound. | 0.00021471 | 35 |
| c5 | RESPONSE_TO_WOUNDING | Genes annotated by the GO term GO:0009611. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. | 0.0002286 | 17 |
| c5 | PLASMA_MEMBRANE | Genes annotated by the GO term GO:0005886. The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. | 0.00026109 | 59 |
| c5 | REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS | Genes annotated by the GO term GO:0045072. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. | 0.00027643 | 4 |