Coarse module 18 - T-cell activation - TCR/CD3 complex genes, their downstream effectors


Publications with genes in this module (limited to maximum 200 per gene):5977 (5751 unique)
Publications with more than one gene in this module:
Pubmed IDGene symbolsTitle
20544728BCL11B,RUNX3Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytes.
17579063BCL11B,TCF7Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway.
17308084BCL11B,TCRAActivation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.
12661009BCL11B,TCRAActivation of HOX11L2 by juxtaposition with 3'-BCL11B in an acute lymphoblastic leukemia cell line (HPB-ALL) with t(5;14)(q35;q32.2).
20952682CD5,CD6A Ligand for CD5 Is CD5.
20881832CD5,CD7Pyogenic Variant of Primary Cutaneous Anaplastic Large-Cell Lymphoma: A Lymphoproliferative Disorder With a Predilection for the Immunocompromized and the Young.
20874514CD5,CD27Changes in blood B cell phenotypes and Epstein-Barr virus load in chronically human immunodeficiency virus-infected patients before and after antiretroviral therapy.
20863894CD5,BCL2Molecular basis of CLL.
20848792CD5,CD7[Flow cytometric analysis of cerebrospinal fluid in the diagnosis of central nervous system leukemia]
20839337CD5,CD27Chronic lymphocytic leukaemia (CLL) and CLL-type monoclonal B-cell lymphocytosis (MBL) show differential expression of molecules involved in lymphoid tissue homing.
20829373CD5,CD7Lymphomatoid gastropathy: a distinct clinicopathological entity of self-limited pseudomalignant NK-cell proliferation.
20818445CD5,CD28Mesenchymal stem cell as salvage treatment for refractory chronic GVHD.
20810246CD5,CD6,CD27Aberrant expression of CD6 on B-cell subsets from patients with Sjogren's syndrome.
20809421CD5,BCL2A study on nm23-H1 expression in diffuse large B-cell lymphoma that was treated with CyclOBEAP plus rituximab therapy.
20736456CD5,BCL2Immunoblastic morphology but not the immunohistochemical GCB/non-GCB classifier predicts outcome in diffuse large B-cell lymphoma in the RICOVER-60 trial of the DSHNHL.
20735454CD5,CD7Flow cytometry as an accurate tool to complement fine needle aspiration cytology in the diagnosis of low grade malignant lymphomas.
20709949CD5,CD27Neisseria lactamica selectively induces mitogenic proliferation of the naive B cell pool via cell surface Ig.
20704789CD5,CD7[Biological characteristics of T-lineage acute lymphoblastic leukemia in 23 children.]
20702104CD5,CD7Peripheral T-cell lymphoma - Not otherwise specified.
20698153CD5,CD7Subcutaneous panniculitis-like T-cell lymphoma in a 19 month-old boy: a case report.
20679053CD5,BCL2[Orbital and ocular adnexal lymphomas. Clinico-pathological correlation in 25 cases]
20662087CD5,CD7,CD96Detection of molecular targets on the surface of CD34+CD38- bone marrow cells in myelodysplastic syndromes.
20654153CD5,CD7[Clinicopathologic features of lymphoplasmacytic lymphoma.]
20557674CD5,CD7CD56-positive diffuse large B-cell lymphoma: possible association with extranodal involvement and bcl-6 expression.
20550670CD5,CD6Evolution of the CD163 family and its relationship to the bovine gamma delta T cell co-receptor WC1.
20531452CD5,CD27Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype.
20490333CD5,BCL2An uncommon case of de novo CD10+ CD5- mantle cell lymphoma mimics follicle center B cell lymphoma.
20480837CD5,BCL2Mucosa-associated lymphoid tissue lymphoma of the appendix vermiformis.
20448385CD5,CD7Immunophenotyping of mature T/NK cell neoplasm presenting as leukemia.
20438120CD5,TXKQuantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice.
20432760CD5,CD7T-lymphoblastic lymphoma with an unusual t(8;14)(q24;q11)--case report.
20383306CD5,CD27A comparative method for processing immunological parameters: developing an "Immunogram".
20381152CD5,CD6Elevated numbers of SCART1+ gammadelta T cells in skin inflammation and inflammatory bowel disease.
20231613CD5,CD27,CD7Minimal residual disease detection by flow cytometry in adult T-cell leukemia/lymphoma.
20155852CD5,CD7Immaturity associated antigens are lost during induction for T cell lymphoblastic leukemia: implications for minimal residual disease detection.
20067170CD5,ZAP70Splenectomy--a therapeutic option in splenic marginal zone cell lymphoma.
20066454CD5,CD7Lineage switch from precursor B cell acute lymphoblastic leukemia to acute monocytic leukemia at relapse.
20046078CD5,CD7Frequent CD7 antigen loss in aggressive natural killer-cell leukemia: a useful diagnostic marker.
20041009CD5,CD7Characterization of acute lymphoblastic leukemia subtypes in moroccan children.
20030918CD5,CD7Cross-lineage expression in 505 patients with acute lymphoblastic leukemia by multiparametric flow cytometry analysis.
20010405CD5,CD7When dead cells tell tales-cutaneous involvement by precursor T-cell acute lymphoblastic lymphoma with an uncommon phenotype.
19965640CD5,CD27Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells.
19933767CD5,CD6Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis.
19918335CD5,CD7Persistent non-neoplastic gammadelta-T cells in cerebrospinal fluid of a patient with hepatosplenic (gammadelta) T cell lymphoma: a case report with 6 years of flow cytometry follow-up.
19916974CD5,CD7Sezary syndrome presenting with 'leonine facies'.
19915381CD5,CD7[Successful treatment of T-cell prolymphocytic leukemia (T-PLL) with fludarabine monophosphate]
19903217CD5,CD7Extragenital lichen sclerosus et atrophicus mimicking cutaneous T-cell lymphoma: report of a case.
19892591CD5,CD27Acute wrist and foot drop associated with hepatitis C virus related mixed cryoglobulinemia: rapid response to treatment with rituximab.
19886534CD5,CD27[Expression CD27 on T and B lymphocytes in hypertrophied adenoids at children with otitis media with effusion]
19876583CD5,CD27Immune changes in post-menopausal osteoporosis: the Immunos study.
19847197CD5,ZAP70Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.
19840468CD5,CD7[Characteristics of fusion gene and immunophenotype in MLL gene rearrangement positive childhood acute lymphoblastic leukemia]
19838774CD5,CD27Long-term cerebrospinal fluid and blood lymphocyte dynamics after rituximab for pediatric opsoclonus-myoclonus.
19779962CD5,CD7Aberrant phenotypes in childhood and adult acute leukemia and its association with adverse prognostic factors and clinical outcome.
19770358CD5,ZAP70High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia.
19734979CD5,CD7Generalized leukaemia cutis from a small cell variant of T-cell prolymphocytic leukaemia presenting with exfoliative dermatitis.
19729201CD5,GATA3Gene expression profiling in mice with enforced Gata3 expression reveals putative targets of Gata3 in double positive thymocytes.
19728759CD5,CD7Immunophenotyping parameters as prognostic factors in T-acute leukemia patients.
19694316CD5,CD7A case report of adult T-cell leukaemia/lymphoma.
19446338CD6,RUNX3The human CD6 gene is transcriptionally regulated by RUNX and Ets transcription factors in T cells.
20890621LEF1,TCF7Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation.
20849841LEF1,AXIN2A network of Wnt, hedgehog and BMP signaling pathways regulates tooth replacement in snakes.
20735988LEF1,AXIN2Differentiation of human neural progenitor cells regulated by Wnt-3a.
20675304LEF1,TCF7Insulin treatment and high-fat diet feeding reduces the expression of three Tcf genes in rodent pancreas.
20454507LEF1,AXIN2GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer.
19956733LEF1,FYN,GATA3Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.
19515997LEF1,TCF7Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.
19346236LEF1,TCF7Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks.
19149881LEF1,AXIN2Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex.
18065431LEF1,TCF7Insertional mutagenesis by the Tol2 transposon-mediated enhancer trap approach generated mutations in two developmental genes: tcf7 and synembryn-like.
17346200LEF1,AXIN2Epigenetic alterations of the Wnt/beta-catenin pathway in human disease.
16424171LEF1,TCF7Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo.
15765502LEF1,TCF7Expression pattern of zebrafish tcf7 suggests unexplored domains of Wnt/beta-catenin activity.
19951976TCF7,ZAP70Gene expression factors as predictors of genetic risk and survival in chronic lymphocytic leukemia.
20190752THEMIS,RUNX3Multiple common variants for celiac disease influencing immune gene expression.
19915147TRAT1,CD3D,LCK,ZAP70Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival.
18485203TRAT1,CD3D,CD3G,TNFRSF25,ZAP70Comparative analysis of transcriptional profiling of CD3+, CD4+ and CD8+ T cells identifies novel immune response players in T-cell activation.
20604962BCL2,CD7Comparative Multi-Epitope-Ligand-Cartography reveals essential immunological alterations in Barrett's metaplasia and esophageal adenocarcinoma.
20957041CD27,CD28Failure of Effector Function of Human CD8 T Cells in NOD/SCID/JAK3 Immunodeficient Mice Transplanted with Human CD34 Hematopoietic Stem Cells. LID - e13109 [pii]
20870003CD27,CD28Increased liver-infiltrating CD8(+)FoxP3(+) regulatory T cells are associated with tumor stage in hepatocellular carcinoma patients.
20861189CD27,CD28Tumor-reactive CD8+ early effector T cells identified at tumor site in primary and metastatic melanoma.
20844584CD27,CD28Functional dichotomy between NKG2D and CD28-mediated co-stimulation in human CD8+ T cells. LID - e12635 [pii]
20833977CD27,CD28GvHD after haploidentical transplant: a novel, MHC-defined rhesus macaque model identifies CD28-negative CD8+ T cells as a reservoir of breakthrough T cell proliferation during costimulation blockade and sirolimus-based immunosuppression.
20817873CD27,CD28Human decidual tissue contains differentiated CD8+ effector-memory T cells with unique properties.
20738423CD27,CD28Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects.
20674505CD27,CD28CD45RA expression on HCMV-specific effector memory CD8+ T cells is associated with the duration and intensity of HCMV replication after transplantation.
20638470CD27,CD28Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise.
20627191CD27,CD28Initial burst of viremia related to CD8 effector memory T cells after living donor liver transplantation in hepatitis C virus-infected recipients.
20571894CD27,CD28IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4+ T (T(H)17) cells in the periphery.
20562332CD27,CD28Levels of cytomegalovirus-specific CD4+ T cells are markedly expanded in patients with B-cell chronic lymphocytic leukaemia and determine the total CD4+ T cell repertoire.
20546884CD27,LCKTranscriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures.
20541243CD27,CD28Profound elevation of CD8+ T cells expressing the intraepithelial lymphocyte marker CD103 (alphaE/beta7 Integrin) in high-grade serous ovarian cancer.
20540811CD27,CD28Influenza A H5N1 and HIV co-infection: case report.
20533391CD27,CD28Multiparametric flow cytometry profiling of neoplastic plasma cells in multiple myeloma.
20465573CD27,CD28High content cellular immune profiling reveals differences between rhesus monkeys and men.
20440767CD27,CD28Features of immune senescence in liver transplant recipients with established grafts.
20439967CD27,CD28Assessment of CD8(+) T cell differentiation in Trypanosoma cruzi-infected children.
20428216CD27,CD28Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype.
20411566CD27,CD28Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection.
20102410CD27,LCKOver-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages.
19801512CD27,RUNX3Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells.
18832576RAB27A,SYTL2Dysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset.
17968951RAB27A,SH2D1AGene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome.
16684812RAB27A,RAB37Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells.
12578829RAB27A,RAB37Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.
12051743RAB27A,RAB37Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains.
19235837SPN,AXIN2Gene expression profiling provides insights into the pathways involved in solid pseudopapillary neoplasm of the pancreas.
19109136CD160,LCKIdentification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation.
19435912CD7,LCKCancer vaccine enhanced, non-tumor-reactive CD8(+) T cells exhibit a distinct molecular program associated with "division arrest anergy".
20876849FYN,LCKMislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas.
20863867FYN,LCKInvolvement of Src family kinase activation in angiotensin II-induced hyperresponsiveness of rat bronchial smooth muscle.
20798388FYN,LCKDEVELOPMENTAL EXPRESSION OF SRC-RELATED TYROSINE KINASES IN THE MOUSE TESTIS.
20533766FYN,LCKEffects of the novel and potent lymphocyte-specific protein tyrosine kinase inhibitor TKM0150 on mixed lymphocyte reaction and contact hypersensitivity in mice.
20471842FYN,LCKDesign and synthesis of new anticancer pyrimidines with multiple-kinase inhibitory effect.
20417561FYN,LCKCD44 interacts directly with Lck in a zinc-dependent manner.
20381867FYN,LCKT cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells.
20346773FYN,LCKCD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.
20190765FYN,LCKA chemical and phosphoproteomic characterization of dasatinib action in lung cancer.
20182632FYN,LCKTOM1L is involved in a novel signaling pathway important for the IL-2 production in Jurkat T cells stimulated by CD3/CD28 co-ligation.
20181696FYN,LCKThe lack of an inherent membrane targeting signal is responsible for the failure of the matrix (M1) protein of influenza A virus to bud into virus-like particles.
20176329FYN,LCK[Neuronal isoforms of Src, Fyn and Lck tyrosine kinases: A specific role for p56lckN in neuron protection]
20164216FYN,LCK,SH2D1A,ZAP70Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display.
20160140FYN,LCKActivation of EphA receptors on CD4+CD45RO+ memory cells stimulates migration.
20126650FYN,LCKRoles of the Src tyrosine kinases Lck and Fyn in regulating gammadeltaTCR signal strength.
20072833FYN,LCKDasatinib.
20049867FYN,ITKGlobal phosphoproteomic effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways.
20049647FYN,SH2D1ARole of SLAM-associated protein in the pathogenesis of autoimmune diseases and immunological disorders.
20028775FYN,LCKThe T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems.
19922956FYN,MLLT3Differential gene expression in chronic inflammatory demyelinating polyneuropathy (CIDP) skin biopsies.
19917692FYN,LCKMAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells.
19825829FYN,LCKChemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells.
19690443FYN,LAT2'-Ethoxy-5'-methoxy-2-(5-methylthienyl)chalcone inhibits collagen-induced protein tyrosine phosphorylation and thromboxane formation during platelet aggregation and adhesion.
19577230FYN,LCKAge-related changes in lck-Vav signaling pathways in mouse CD4 T cells.
19499547FYN,LCKA comprehensive catalogue of functional genetic variations in the EGFR pathway: protein-protein interaction analysis reveals novel genes and polymorphisms important for cancer research.
19426688FYN,LATMorin inhibits Fyn kinase in mast cells and IgE-mediated type I hypersensitivity response in vivo.
19290918FYN,LCKT-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance.
20398001IL2RB,PRKCQGenetics in neuroendocrine immunology: implications for rheumatoid arthritis and osteoarthritis.
20049410IL2RB,PRKCQA functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis.
19228591NT5E,THY1Isolation and culture of epithelial progenitors and mesenchymal stem cells from human endometrium.
20412760RUNX3,GATA3Antisocial networking in T helper cells.
20399120RUNX3,GATA3The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma.
20126642RUNX3,ITKItk derived signals regulate the expression of Th-POK and controls the development of CD4 T cells.
19933870RUNX3,GATA3The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.
19696430RUNX3,GATA3CD4-CD8 lineage differentiation: Thpok-ing into the nucleus.
20081873CD226,CD96A novel interface consisting of homologous immunoglobulin superfamily members with multiple functions.
19404979CD226,CD96DNAX accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by Vgamma9Vdelta2 T cells.
17621371CD226,CD96The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens.
16904340CD226,CD96The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance.
15640804CD226,CD96Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141.
20716621CD28,GATA3Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.
20716329CD28,LCKTranscriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases.
20667993CD28,GATA3T-cell phenotype in protocol renal biopsy from transplant recipients treated with Belatacept-mediated co-stimulatory blockade.
20498361CD28,GATA3Phenotypic alterations of dendritic cells are involved in suppressive activity of trichosanthin-induced CD8+CD28- regulatory T cells.
20421644CD28,LCKCD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors.
20478055CD3D,CD3E,CD3G,THY1Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study.
19222422CD3D,ITKA haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis.
16264327CD3D,CD3E,CD3GCD3 deficiencies.
15546002CD3D,CD3ESevere combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.
11261926CD3D,CD3E,CD3GA major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9.
7757067CD3D,CD3EAnalysis of the CD3 gene region and type 1 diabetes: application of fluorescence-based technology to linkage disequilibrium mapping.
1386345CD3D,CD3ESomatic cell mapping of T-cell receptor CD3 complex and CD8 genes in cattle.
1720549CD3D,CD3GIdentification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.
1686010CD3D,TCRAHLA and non-HLA genetic factors in Japanese IDDM.
1829960CD3D,CD3GCD3G is within 200 kb of the leukemic t(4;11) translocation breakpoint.
2251277CD3D,CD3GMapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome.
1981047CD3D,CD3E,CD3GA physical linkage group in human chromosome band 11q23 covering a region implicated in leukocyte neoplasia.
1982251CD3D,TCRANon-HLA genetic factors and insulin dependent diabetes mellitus in the Japanese: TCRA, TCRB and TCRG, INS, THY1, CD3D and ETS1.
2331673CD3D,CD3E,CD3GPhysical mapping of the human chromosome 11q23 region containing the ataxia-telangiectasia locus.
2137107CD3D,CD3GDNase hypersensitivity and methylation of the human CD3G and D genes during T-cell development.
3248386CD3D,CD3EMapping studies and expression of genes located on human chromosome 11, band q23.
17371980CD3E,ZAP70Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition.
20656931GATA3,MLLT3FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
20117130GATA3,LCKDemonstration of T cell and macrophage progenitors in carp (Cyprinus carpio) kidney hematopoietic tissues. Development of clonal assay system for carp hematopoietic cells.
19375173GATA3,LCKCo-culture of carp (Cyprinus carpio) kidney haematopoietic cells with feeder cells resulting in long-term proliferation of T-cell lineages.
18769122GATA3,TXKGene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment.
20305788ITK,LCKT cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.
20237289ITK,LAT,LCKDisrupting the intermolecular self-association of Itk enhances T cell signaling.
20220094ITK,LCKUncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma.
19955438ITK,LAT,LCKItk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.
19427038ITK,LATPI3 kinase function is vital for the function but not formation of LAT-mediated signaling complexes.
19290923ITK,TXKTec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.
19161832ITK,TXKPhylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5.
19074136ITK,LCKCbl enforces an SLP76-dependent signaling pathway for T cell differentiation.
18941202ITK,TXKSelective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.
17371991ITK,ZAP70Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals.
15817477ITK,TXKDynamic regulation of Tec kinase localization in membrane-proximal vesicles of a T cell clone revealed by total internal reflection fluorescence and confocal microscopy.
15492005ITK,TXKSHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.
14993283ITK,TXKExpression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec.
12798690ITK,TXKDeterminants of intra versus intermolecular self-association within the regulatory domains of Rlk and Itk.
20856802LAT,ZAP70Modulation of cell signaling networks after CTLA4 blockade in patients with metastatic melanoma.
20511667LAT,LCKDisturbed expression of the T-cell receptor/CD3 complex and associated signaling molecules in CD30+ T-cell lymphoproliferations.
20460646LAT,LCKT cell activation at the immunological synapse: vesicles emerge for LATer signaling.
20153839LAT,LCKLimited cholesterol depletion causes aggregation of plasma membrane lipid rafts inducing T cell activation.
19887607LAT,ZAP70NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells.
19833736LAT,LCKLeukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of multiple kinases.
19701892LAT,THY1Peripheral Thy1+ lymphocytes rearranging TCR-gammadelta genes in LAT-deficient mice.
19520156LAT,ZAP70Tregs utilize beta-galactoside-binding protein to transiently inhibit PI3K/p21ras activity of human CD8+ T cells to block their TCR-mediated ERK activity and proliferation.
19494291LAT,LCKSequential cooperation of CD2 and CD48 in the buildup of the early TCR signalosome.
20856869LCK,ZAP70Role of CD45 signaling pathway in galactoxylomannan-induced T cell damage.
20851766LCK,ZAP70RhoH modulates pre-TCR and TCR signalling by regulating LCK.
20696918LCK,ZAP70T-cell receptor complex is essential for Fas signal transduction.
20332426LCK,ZAP70Two receptors, two kinases, and T cell lineage determination.
19786978LCK,THY1Thymocyte expansion and maturation: crosstalk of CD44v6 on thymocytes and panCD44 on stroma cells.
19561113LCK,ZAP70Mechanisms of opioid-mediated inhibition of human T cell receptor signaling.
19530243LCK,TCRARecurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice.
19403707LCK,ZAP70Vitamin E reverses impaired linker for activation of T cells activation in T cells from aged C57BL/6 mice.
18260110SH2D1A,ZAP70Genome wide analysis of pathogenic SH2 domain mutations.