| SYMBOL | TITLE | MIN | MAX | NCBI
human
gene
summary |
|---|
| EXO1 | exonuclease 1 | 5.72 | 10.41 | NCBI mm gene |
| PASK | PAS domain containing serine/threonine kinase | 5.97 | 11.35 | NCBI mm gene |
| DTL | denticleless homolog (Drosophila) | 4.76 | 8.90 | NCBI mm gene |
| FAM54A | family with sequence similarity 54, member A | 4.13 | 8.86 | NCBI mm gene |
| GM8681 | predicted gene 8681 | 6.19 | 9.81 | NCBI mm gene |
| CDC6 | cell division cycle 6 homolog (S. cerevisiae) | 5.86 | 10.44 | NCBI mm gene |
| FIGNL1 | fidgetin-like 1 | 6.77 | 12.22 | NCBI mm gene |
| EME1 | essential meiotic endonuclease 1 homolog 1 (S. pombe) | 3.92 | 8.91 | NCBI mm gene |
| TK1 | thymidine kinase 1 | 3.87 | 8.74 | NCBI mm gene |
| RAD51L1 | RAD51-like 1 (S. cerevisiae) | 6.27 | 9.22 | NCBI mm gene Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| 4930427A07RIK | RIKEN cDNA 4930427A07 gene | 5.72 | 10.51 | NCBI mm gene |
| CENPK | centromere protein K | 5.74 | 9.14 | NCBI mm gene |
| E2F3 | E2F transcription factor 3 | 4.53 | 10.06 | NCBI mm gene |
| TRIP13 | thyroid hormone receptor interactor 13 | 5.37 | 9.25 | NCBI mm gene |
| CENPH | centromere protein H | 4.85 | 10.28 | NCBI mm gene |
| CENPM | centromere protein M | 6.03 | 9.10 | NCBI mm gene |
| CDC45L | cell division cycle 45 homolog (S. cerevisiae) | 5.20 | 8.82 | NCBI mm gene |
| CHAF1A | chromatin assembly factor 1, subunit A (p150) | 5.32 | 8.55 | NCBI mm gene |
| UHRF1 | ubiquitin-like, containing PHD and RING finger domains, 1 | 5.15 | 9.17 | NCBI mm gene |
| LMNB1 | lamin B1 | 5.05 | 9.87 | NCBI mm gene Summary: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. [provided by RefSeq]. |
| 2610318N02RIK | RIKEN cDNA 2610318N02 gene | 6.07 | 8.60 | NCBI mm gene |
| RAD51 | RAD51 homolog (S. cerevisiae) | 4.83 | 9.31 | NCBI mm gene Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
| MYBL2 | myeloblastosis oncogene-like 2 | 4.80 | 10.07 | NCBI mm gene |
| MCM10 | minichromosome maintenance deficient 10 (S. cerevisiae) | 7.24 | 9.56 | NCBI mm gene |
| E2F1 | E2F transcription factor 1 | 4.69 | 8.59 | NCBI mm gene |
| DSN1 | DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) | 7.17 | 12.37 | NCBI mm gene |
| CCNE2 | cyclin E2 | 5.99 | 10.44 | NCBI mm gene |
| RAD54B | RAD54 homolog B (S. cerevisiae) | 6.60 | 11.58 | NCBI mm gene Summary: The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq]. |
| RAD54L | RAD54 like (S. cerevisiae) | 5.86 | 9.93 | NCBI mm gene Summary: The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein. |
| HMGB2 | high mobility group box 2 | 4.33 | 7.05 | NCBI mm gene |
| CDK6 | cyclin-dependent kinase 6 | 5.16 | 10.35 | NCBI mm gene Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]. |
| POLE | polymerase (DNA directed), epsilon | 6.54 | 9.98 | NCBI mm gene |
| RFC5 | replication factor C (activator 1) 5 | 6.26 | 12.20 | NCBI mm gene |
| FANCD2 | Fanconi anemia, complementation group D2 | 5.68 | 8.83 | NCBI mm gene Summary: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq]. |
| ANUBL1 | AN1, ubiquitin-like, homolog (Xenopus laevis) | 5.17 | 10.36 | NCBI mm gene |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 5.05 | 9.67 | NCBI mm gene |
| RAD51AP1 | RAD51 associated protein 1 | 4.85 | 8.45 | NCBI mm gene |
| LIG1 | ligase I, DNA, ATP-dependent | 5.02 | 8.04 | NCBI mm gene Summary: LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. [provided by RefSeq]. |
| MLF1IP | myeloid leukemia factor 1 interacting protein | 4.89 | 8.43 | NCBI mm gene |
| CENPN | centromere protein N | 5.79 | 10.07 | NCBI mm gene |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 8.22 | 10.88 | NCBI mm gene |
| FANCA | Fanconi anemia, complementation group A | 6.02 | 9.26 | NCBI mm gene Summary: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq]. |
| MNS1 | meiosis-specific nuclear structural protein 1 | 5.81 | 9.91 | NCBI mm gene |
| SPC24 | SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) | 5.49 | 10.08 | NCBI mm gene |
| CHEK1 | checkpoint kinase 1 homolog (S. pombe) | 5.39 | 11.05 | NCBI mm gene |
| ZWILCH | Zwilch, kinetochore associated, homolog (Drosophila) | 4.28 | 9.04 | NCBI mm gene |