Project Introduction
- Welcome to immgenT, the meta world of mouse T cells!
- The immgen T Open Source Project is a collaborative effort involving 100 participants across 41 laboratories, working together to create the most comprehensive atlas of T cells in the mouse immune system. The goal is to profile every T cell in every body location and capture their diverse states in response to immunological challenges. Profiling was performed at the single-cell level, integrating mRNA sequencing, surface protein expression (CITE-seq/TotalSeq), and TCR-V sequencing (paired α/β chains). The TotalSeq panel of 128 antibodies was developed in collaboration with BioLegend. The first draft of the T cell universe consists of 627,692 mature T cells, analyzed across 738 samples and 80 experiments, revealing a structured landscape of 8 major populations and 114 distinct subpopulations. Following ImmGen's tradition of open science, all data are now publicly available through (the Rosetta browser), developed by Dania Mallah, Niket Patel, and Brinda Vijaykumar. You can explore specific datasets, compare them to other T cell references, and navigate a flow cytometry-like visualization of surface marker expression.
- Go T!
- List of participants:
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Domenic Abbondanza, Nika Abdollahi, Judith Agudo, Marisa Alegre, Derek Bangs, Olga Barreiro del Rio, Gavyn Bee, Sam Behar, Tal Ben Tovim, Christophe Benoist, Katharine Block, Sam Borys, Remy Bosselut, Maria Brbic, Laurent Brossay, Ken Cadwell, Serge Candéias, Peter Carbonetto, Odhran Casey, Alexandra Cassano, Evelyn Chang, Alexander Chervonsky, Josh Choi, Myriam Croze, Jill Davis, Can Ergen-Behr, Enxhi Ferraj, Maurizio Fiusco, Antoine Freuchet, Sarah Gaffen, Giovanni Galleti, Laurent Gapin, Lizzie Garcia-Rivera, Véronique Giuducelli, Anna-Maria Globig, Ananda Goldrath, Xutong Gong, Sara Hamilton Hart, Taylor Heim, Jun Huh, Iliyan Iliev, Charlotte Imianowski, Bana Jabri, Steve Jameson, Marc Jenkins, Susan Kaech, Joonsoo Kang, Dan Kaplan, Sofia Kossida, Mitch Kronenberg, Vijay Kuchroo, Takato Kusakabe, Rocky Lai, Sarah Kate Lane-Reticker, Andrea Lebron-Figueroa, Zhitao Liang, Woan-Yu Lin, Aaron Liu, Mariya London, Erin Lucas, Ian Magill, Ankit Malik, Dania Mallah, Julia Merkenschlager, Nathan Morris, Sara Mostafavi, Stefan Muljo, Armita Nourmohammad, Michel Nussenzweig, Kevin Osum, Siba Smarak Panigrahi, Jinseok Park, Niket Patel, Marion Pepper, Val Piekarsa, Sara Quon, Shika Ramanan, Shanelle Reilly, Stefan Schattgen, Tal Shay, Tomoyo Shinkawa, David Sinclair, Nalat Siwapornchai, Stefani Spranger, Michael Starnbach, Matthew Stephens, Claire Thefane, Paul Thomas, Melanie Vacchio, Dario Vignali, Brinda Vijaykumar, Jordan Voisine, Ulrich von Andrian, Tianze Wang, Eric Weiss, Alia Welsh, Liang Yang, Nir Yosef, David Zemmour, Shanshan Zhang
- Read the Nature Immunology Correspondence here.
